New Publications and Research Highlights


Development of the corticospinal system & skilled motor development

Selected Review articles:

Martin JH, Friel K, Salimi I, Chakrabarty S. Corticospinal Development. In: Encyclopedia of Neuroscience, volume 3, pp. 302-214. (Ed) L. Squire. Oxford: Academic Press. (2009).

Martin JH, Chakrabarty S, Friel K. Harnessing activity- and use-dependent plasticity to reconstruct the damaged corticospinal system and restore motor function. Developmental Medicine & Child Neurology 53 (suppl4): 9-13, 2011.

Friel KM, Williams PTJA, Serradj N, Chakrabarty S, Martin JH. Activity-Based Therapies for Repair of the Corticospinal System Injured during Development. Frontiers in Neurology. (2014), 5:229.

Selected Research articles:

Gu Z, Kalambogias J …  Martin JH, Yoshida Y. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Science (2017), 357:400-404.

Gu Z, Serradj N, Ueno M, Liang M, Li J, Baccei ML, Martin JH, Yoshida Y. Skilled Movements Require Non-apoptotic Bax/Bak Pathway-Mediated Corticospinal Circuit Reorganization. Neuron (2017), 94:626-641.

Chakrabarty S, Shulman, B, Martin JH. Activity-dependent co-development of the corticospinal system and target interneurons in the cervical spinal cord. J Neurosci. (2009) 29:8816-8827.

Friel KM, Chakrabarty S, Kuo H-C, Martin JH. Using motor behavior during an early critical period to restore skilled limb movement after damage to the corticospinal motor system during development. J. Neuroscience (2012) 32:9265-9276.

Paixão S, Balijepalli A, Serradj N, Martin JH, Klein R. EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron (2013) 80: 1407 – 1420.

Williams P, Kim S, Martin JH. Postnatal maturation of the red nucleus motor map depends on rubrospinal connections with forelimb motor pools. Journal of Neuroscience (2014) 34:4432-4441.

Serradj N, Paixão S, Sobocki T, Feinberg M, Klein R, Kullander K, Martin JH. EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. Journal of Neuroscience (2014) 34: 5211-5221.

Highlighted by the Journal of Neuroscience as the featured article for Development/Plasticity/Repair: “Reaching Becomes Bilateral When CST Axons Project Bilaterally”

Williams P, Martin JH. Motor cortex activity organizes the developing rubrospinal system. Journal of Neuroscience (2015) 35:13363-13374.

Adult motor system repair

Selected Review articles:

Campos LC, Ambron RT, Martin JH Bridge over troubled waters. NeuroReport 15:2691-2694, 2004

Martin JH. Systems Neurobiology of Restorative Neurology and Future Directions For Repair of the Damaged Motor Systems. Clinical Neurology and Neurosurgery (2012) 114:515-523.

Carmel JB, Martin JH. Motor cortex electrical stimulation augments sprouting of the corticospinal tract and promotes recovery of motor function. Frontiers in Integrative Neuroscience. (2014) doi: 10.3389/fnint.2014.00051

Selected Research articles:

Zareen N, Shinozaki M, Ryan D, Alexander H, Amer A, Truong D, Khadka N, Sarkar A, Neaeem S, Bikson M, Martin J. Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury. Exp Neurol (2017 in press).

Campos L, Meng Z, Hu G, Chiu D, Ambron RT, Martin JH. Engineering novel spinal circuits to promote recovery after spinal injury. J Neuroscience (2004) 24:2090-2101.

J Neuroscience (2004) 24 (9); Spinal cord bypass surgery.

Nature Reviews: Neuroscience (2004) 5:257; Bridging the gap

Carmel JB, Berrol LJ, Brus-Ramer M, Martin JH. Chronic Electrical Stimulation of the Intact Corticospinal System After Unilateral Injury Restores Skilled Locomotor Control and Promotes Spinal Axon Outgrowth. J. Neurosci. (2010) 30:10918-10926.

Tan A, Chakrabarty S, Martin JH. Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia. J. Neuroscience (2012) 32(37):12896 –12908.

Carmel JB, Kimura H, Martin JH. Electrical Stimulation of Motor Cortex in the Uninjured Hemisphere after Chronic Unilateral Injury Promotes Recovery of Skilled Locomotion through Ipsilateral Control. Journal of Neuroscience (2014) 34:462-466.

Jiang Y, Zaaimi B, Martin JH. Competition with primary sensory afferents drives remodeling of corticospinal axons in mature spinal motor circuits. J Neuroscience (2015) In press.

Song W, Amer Z, Ryan D, Martin JH. Effects of theta burst motor cortex stimulation can be potentiated by spinal cathodal DC stimulation to promote corticospinal system plasticity and motor recovery after injury. Exp Neurology (2016) 277:46-57.